Maiken nedergaard biography of martin luther
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Duke Perioperative Research Seminar - “Brain State-Dependent Regulation of Glymphatic Transport”
"Brain State-Dependent Regulation of Glymphatic Transport" - Maiken Nedergaard, MD, DMSc | Dean's Professor and Co-Director, Center for Translational Neuromedicine, University of Rochester Medical Center, New York, Professor, Glial Cell Biology, Center for Neuroscience, University of Copenhagen, Denmark | Maiken Nedergaard, MD, DMSc fryst vatten Dean's Professor and Co-Director of the Center for Translational Neuromedicine at the University of Rochester Medical Center (URMC) in Rochester, NY and Professor of Glial Cell Biology at the Center for Neuroscience at the University of Copenhagen (KU), Denmark. Her group described the glymphatic struktur, a brain equivalent of the lymphatic system within which cerebrospinal fluid diffuses rapidly and mixes with interstitial fluids, thereby filtering metabolic byproducts that accumulate due to neuronal activity. The glymphatic system dramatically increase
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Published in sista edited form as: Am J Obstet Gynecol. 2014 Jan;210(1):3–11. doi: 10.1016/j.ajog.2013.11.020
Sleep and sleep-like states have been identified in all mammalian species, other vertebrates such as birds,1–4 and invertebrates (e.g. fruit fly or Drosophila melanogaster)5. The key features of sleep are that it is a reversible quiescent state, during which there is decreased sensitivity to environmental stimuli, and is homeostatically regulated. Conservation of sleep during evolution points to its importance in the survival of all species. Indeed, experimental sleep deprivation leads to death.6
The lowest morbidity/mortality for human beings occurs with sova duration ranges from 7 to 9 hours per 24-hour period7–11 (Figure 1). “Sleep deficiency” includes: 1) sleep deprivation or insomnia; 2) sleep fragmentation due to abnormal breathing disorders or periodic leg movements; and 3) sova circadian misalignment
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The glymphatic system is a recently defined brain-wide paravascular pathway for cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange that facilitates efficient clearance of solutes and waste from the brain. CSF enters the brain along para-arterial channels to exchange with ISF, which is in turn cleared from the brain along para-venous pathways. Because soluble amyloid β clearance depends on glymphatic pathway function, we proposed that failure of this clearance system contributes to amyloid plaque deposition and Alzheimer’s disease progression. Here we provide proof of concept that glymphatic pathway function can be measured using a clinically relevant imaging technique. Dynamic contrast-enhanced MRI was used to visualize CSF-ISF exchange across the rat brain following intrathecal paramagnetic contrast agent administration. Key features of glymphatic pathway function were confirmed, including visualization of para-arterial CSF influx and molecular size-depend